LMPD Database

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LMP003591

UniProt Annotations

Entry Information
Gene Nameprohibitin 2
Protein EntryO35129_MOUSE
UniProt IDO35129
SpeciesMouse
Comments
Comment typeDescription
Developmental StageThroughout gestation, highly expressed in brown fat, heart, liver, developing renal tubules and neurons, and detected at lower levels in tissues such as lung and exocrine pancreas.
FunctionActs as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging. {ECO:0000250|UniProtKB:Q99623, ECO:0000269|PubMed:12878603, ECO:0000269|PubMed:15140878}.
SimilarityBelongs to the prohibitin family.
Subcellular LocationMitochondrion inner membrane. Cytoplasm. Nucleus. Note=Also cytoplasmic and nuclear.
SubunitInteracts with ZNF703 (By similarity). Interacts with STOML2 (By similarity). Interacts with PHB, ESR1, HDAC1 and HDAC5. {ECO:0000250, ECO:0000269|PubMed:11302691, ECO:0000269|PubMed:12878603, ECO:0000269|PubMed:15140878}.
Tissue SpecificityWidely expressed in different tissues. {ECO:0000269|PubMed:11302691, ECO:0000269|PubMed:15140878, ECO:0000269|PubMed:8070406}.