LMPD Database


UniProt Annotations

Entry Information
Gene Nameheparan sulfate 2-O-sulfotransferase 1
Protein EntryHS2ST_HUMAN
UniProt IDQ7LGA3
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q7LGA3-1; Sequence=Displayed; Name=2; IsoId=Q7LGA3-2; Sequence=VSP_014062, VSP_014064; Note=No experimental confirmation available.; Name=3; IsoId=Q7LGA3-3; Sequence=VSP_014063; Note=No experimental confirmation available.;
FunctionCatalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high- affinity ligand-binding interactions and signaling processes. Mediates 2-O-sulfation of both L-iduronyl and D-glucuronyl residues (By similarity).
Sequence CautionSequence=BAA32293.2; Type=Erroneous initiation; Evidence= ;
SimilarityBelongs to the sulfotransferase 3 family.
Subcellular LocationGolgi apparatus membrane ; Single-pass type II membrane protein .
SubunitHomotrimer. Interacts with the C5-epimerase GLCE (By similarity).