LMPD Database

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LMP003430

UniProt Annotations

Entry Information
Gene NameN-acyl phosphatidylethanolamine phospholipase D
Protein EntryNAPEP_MOUSE
UniProt IDQ8BH82
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityAn N-acylphosphatidylethanolamine + H(2)O = an N-acylethanolamine + a 1,2-diacylglycerol 3-phosphate.
CofactorName=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 1 or 2 zinc ions per subunit. {ECO:0000250};
Enzyme RegulationActivity is stimulated by divalent cations. {ECO:0000250}.
FunctionHydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce N-acylethanolamines (NAEs) and phosphatidic acid. Responsible for the generation of anandamide (N- arachidonoylethanolamine), the ligand of cannabinoid and vanilloid receptors. {ECO:0000269|PubMed:14634025}.
SimilarityBelongs to the NAPE-PLD family. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000250}.
SubunitMonomer. {ECO:0000250}.
Tissue SpecificityWidely expressed. Highest expression in brain, kidney and testis (at protein level). {ECO:0000269|PubMed:14634025}.