LMPD Database

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LMP003427

UniProt Annotations

Entry Information
Gene Namephospholipid scramblase 2
Protein EntryPLS2_MOUSE
UniProt IDQ9DCW2
SpeciesMouse
Comments
Comment typeDescription
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250};
DomainThe N-terminal proline-rich domain (PRD) is required for phospholipid scramblase activity. {ECO:0000250}.
FunctionMay mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.
SimilarityBelongs to the phospholipid scramblase family. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Tissue SpecificityExpressed in erythrocyte membranes, blood platelets, blood leukocytes, T- and B-lymphocytes, vascular endothelium, spleen, thymus, prostate, testis, uterus, intestine and colon.