LMPD Database

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LMP003345

UniProt Annotations

Entry Information
Gene Namephosphoinositide-3-kinase, regulatory subunit 5
Protein EntryPI3R5_HUMAN
UniProt IDQ8WYR1
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8WYR1-1; Sequence=Displayed; Name=2; IsoId=Q8WYR1-2; Sequence=VSP_016388; Note=No experimental confirmation available.;
DiseaseAtaxia-oculomotor apraxia 3 (AOA3) [MIM
DomainThe heterodimerization region allows the binding to the catalytic subunit.
Enzyme RegulationGreatly activated by G gamma proteins.
FunctionRegulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG (By similarity).
Subcellular LocationNucleus . Cytoplasm {ECO
SubunitHeterodimer of a catalytic subunit (PIK3CG/p120) and a regulatory (PIK3R5a/p101) subunit. Interacts with beta-gamma G protein dimers.
Tissue SpecificityUbiquitously expressed with high expression in fetal brain compared to adult brain. Abundant expression is observed in cerebellum, cerebral cortex, cerebral meninges, and vermis cerebelli. {ECO