LMPD Database

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LMP003230

UniProt Annotations

Entry Information
Gene Nameglycerophosphodiester phosphodiesterase domain containing 2
Protein EntryGDPD2_MOUSE
UniProt IDQ9ESM6
SpeciesMouse
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=97.2 mM for glycerophosphoinositol {ECO:0000269|PubMed:19596859}; Vmax=1.9 nmol/min/mg enzyme {ECO:0000269|PubMed:19596859};
Catalytic Activity1-(sn-glycero-3-phospho)-1D-myo-inositol + H(2)O = glycerol + 1D-myo-inositol 1-phosphate.
CautionThe catalytic domain of Gdpd2 is oriented extracellularly; Glycerophosphoinositol is hydrolyzed in the medium of cells overexpressing Gdpd2, whereas intracellular levels of glycerophosphoinositol is not affected. {ECO:0000305}.
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108;
Developmental StageUp-regulated during osteoblast differentiation. Detected at low levels in mature osteoblasts.
FunctionHas glycerophosphoinositol inositolphosphodiesterase activity and specifically hydrolyzes glycerophosphoinositol, with no activity for other substrates such as glycerophosphoinositol 4- phosphate, glycerophosphocholine, glycerophosphoethanolamine, and glycerophosphoserine. Accelerates the program of osteoblast differentiation and growth. May play a role in remodeling of the actin cytoskeleton. {ECO:0000269|PubMed:12933806, ECO:0000269|PubMed:19596859}.
SimilarityBelongs to the glycerophosphoryl diester phosphodiesterase family. {ECO:0000305}.
SimilarityContains 1 GP-PDE domain. {ECO:0000305}.
Subcellular LocationCell membrane {ECO:0000269|PubMed:12933806}; Multi-pass membrane protein {ECO:0000269|PubMed:12933806}. Cytoplasm {ECO:0000269|PubMed:12933806}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12933806}. Note=Colocalizes with the actin cytoskeleton.
Tissue SpecificityDetected in spleen, femur and calvaria. {ECO:0000269|PubMed:12933806, ECO:0000269|PubMed:15276213}.