LMPD Database

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LMP003229

UniProt Annotations

Entry Information
Gene Namenudix (nucleoside diphosphate linked moiety X)-type motif 10
Protein EntryNUD10_HUMAN
UniProt IDQ8NFP7
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=0.088 uM for PP-InsP5 {ECO
Catalytic ActivityDiphospho-myo-inositol polyphosphate + H(2)O = myo-inositol polyphosphate + phosphate.
Catalytic ActivityP(1),P(5)-bis(5'-adenosyl)pentaphosphate + H(2)O = adenosine 5'-tetraphosphate + AMP.
Catalytic ActivityP(1),P(6)-bis(5'-adenosyl)hexaphosphate + H(2)O = adenosine 5'-pentaphosphate + AMP.
CofactorName=Mg(2+); Xref=ChEBI
FunctionCleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.
SimilarityBelongs to the Nudix hydrolase family. DIPP subfamily.
SimilarityContains 1 nudix hydrolase domain.
Subcellular LocationCytoplasm .
Tissue SpecificityMainly expressed in testis and, at lower level in brain. According to PubMed:12121577, it is widely expressed.