LMPD Database

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LMP003227

UniProt Annotations

Entry Information
Gene Namepolypeptide N-acetylgalactosaminyltransferase-like 5
Protein EntryGLTL5_HUMAN
UniProt IDQ7Z4T8
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7Z4T8-1; Sequence=Displayed; Name=2; IsoId=Q7Z4T8-2; Sequence=VSP_011227, VSP_011228; Note=No experimental confirmation available.;
CautionIn contrast to other members of the family, lacks the C- terminal ricin B-type lectin domain, which contributes to the glycopeptide specificity. No glycosyltransferase activity has been detected in an in vitro assay (PubMed:24398516).
CofactorName=Mn(2+); Xref=ChEBI
DiseaseNote=Defects in GALNTL5 have been found in a patient with primary infertility due to asthenozoospermia.
DomainThere are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
FunctionProbable inactive glycosyltransferase required during spermatid development. May participate to protein loading into the acrosomes and accumulation of ubiquitin-proteasome systems around the head-tail coupling apparatus region.
Sequence CautionSequence=AAM20912.1; Type=Frameshift; Positions=114, 122; Evidence= ; Sequence=AAP97318.1; Type=Frameshift; Positions=114, 122; Evidence= ;
SimilarityBelongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
Subcellular LocationLate endosome membrane ; Single-pass type II membrane protein . Note=Localizes to the juxtanuclear region, possibly the late endosome. Not localized in the Golgi apparatus in round spermatids (By similarity).
Tissue SpecificityMainly expressed in testis. Weakly or not expressed in other tissues.
Web ResourceName=Functional Glycomics Gateway - GTase; Note=Putative polypeptide N-acetylgalactosaminyltransferase-like protein 5; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_498";
Web ResourceName=GGDB; Note=GlycoGene database; URL="http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=GALNTL5";