LMPD Database

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LMP003184

UniProt Annotations

Entry Information
Gene Nameglycerophosphodiester phosphodiesterase domain containing 2
Protein EntryGDPD2_HUMAN
UniProt IDQ9HCC8
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9HCC8-1; Sequence=Displayed; Name=2; IsoId=Q9HCC8-2; Sequence=VSP_042622; Note=No experimental confirmation available.; Name=3; IsoId=Q9HCC8-3; Sequence=VSP_042623; Note=No experimental confirmation available.;
Catalytic Activity1-(sn-glycero-3-phospho)-1D-myo-inositol + H(2)O = glycerol + 1D-myo-inositol 1-phosphate.
CautionThe catalytic domain of GDPD2 is oriented extracellularly; Glycerophosphoinositol is hydrolyzed in the medium of cells overexpressing Gdpd2, whereas intracellular levels of glycerophosphoinositol is not affected.
CofactorName=Ca(2+); Xref=ChEBI
FunctionHas glycerophosphoinositol inositolphosphodiesterase activity and specifically hydrolyzes glycerophosphoinositol, with no activity for other substrates such as glycerophosphoinositol 4- phosphate, glycerophosphocholine, glycerophosphoethanolamine, and glycerophosphoserine. Accelerates the program of osteoblast differentiation and growth. May play a role in remodeling of the actin cytoskeleton (By similarity).
Sequence CautionSequence=BAA91014.1; Type=Frameshift; Positions=397; Evidence= ;
SimilarityBelongs to the glycerophosphoryl diester phosphodiesterase family.
SimilarityContains 1 GP-PDE domain.
Subcellular LocationCell membrane; Multi-pass membrane protein. Cytoplasm. Cytoplasm, cytoskeleton . Note=Colocalizes with the actin cytoskeleton.