LMPD Database

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LMP003160

UniProt Annotations

Entry Information
Gene Namephosphatidic acid phosphatase type 2 domain containing 1A
Protein EntryPPC1A_HUMAN
UniProt IDQ5VZY2
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q5VZY2-1; Sequence=Displayed; Name=2; IsoId=Q5VZY2-2; Sequence=VSP_025238; Note=No experimental confirmation available.; Name=3; IsoId=Q5VZY2-3; Sequence=VSP_025237; Note=No experimental confirmation available.; Name=4; IsoId=Q5VZY2-4; Sequence=VSP_025239, VSP_025240; Note=No experimental confirmation available.;
Biophysicochemical PropertiesKinetic parameters: KM=104 uM for diacylglycerol pyrophosphate ; KM=506 uM for phosphatidate ; KM=580 uM for lysophosphatidate ;
Catalytic ActivityA 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate.
Enzyme RegulationInhibited by N-ethylmaleimide.
FunctionDisplays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of phosphatidic acid to diacylglycerol.
Sequence CautionSequence=CAH70333.1; Type=Erroneous gene model prediction; Evidence= ;
SimilarityBelongs to the PA-phosphatase related phosphoesterase family.
Subcellular LocationMembrane ; Multi-pass membrane protein .
Tissue SpecificityExpressed mainly to the brain, kidney and testis, and to a lesser extent the bone marrow, thymus, prostate, liver and uterus.