LMPD Database

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LMP003136

UniProt Annotations

Entry Information
Gene Namenudix (nucleoside diphosphate linked moiety X)-type motif 12
Protein EntryNUD12_MOUSE
UniProt IDQ9DCN1
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9DCN1-1; Sequence=Displayed; Name=2; IsoId=Q9DCN1-2; Sequence=VSP_014280, VSP_014281; Note=No experimental confirmation available.;
Catalytic ActivityNAD(+) + H(2)O = AMP + NMN.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
FunctionHydrolyzes NAD(P)H to NMNH and AMP (2',5'-ADP), and diadenosine diphosphate to AMP. Has also activity towards NAD(P)(+), ADP-ribose and diadenosine triphosphate. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle (By similarity). {ECO:0000250}.
SimilarityBelongs to the Nudix hydrolase family. NudC subfamily. {ECO:0000305}.
SimilarityContains 1 nudix hydrolase domain. {ECO:0000255|PROSITE-ProRule:PRU00794}.
SimilarityContains 3 ANK repeats. {ECO:0000255|PROSITE- ProRule:PRU00023}.
Subcellular LocationPeroxisome {ECO:0000250}.