LMPD Database

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LMP003113

UniProt Annotations

Entry Information
Gene Name3-oxoacid CoA transferase 2B
Protein EntrySCO2B_MOUSE
UniProt IDQ9ESL0
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivitySuccinyl-CoA + a 3-oxo acid = succinate + a 3- oxoacyl-CoA. {ECO:0000255|PROSITE-ProRule:PRU10034}.
FunctionKey enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity). Probably play and important roles in the energy metabolism of spermatozoa. {ECO:0000250}.
PathwayKetone metabolism; succinyl-CoA degradation; acetoacetyl- CoA from succinyl-CoA: step 1/1.
SimilarityBelongs to the 3-oxoacid CoA-transferase family. {ECO:0000305}.
Subcellular LocationMitochondrion {ECO:0000250}.
SubunitHomodimer. {ECO:0000250}.
Tissue SpecificityTestis specific. Expressed in late spermatids. Accumulates during spermiogenesis. Also detected in the midpiece of spermatozoa. {ECO:0000269|PubMed:11090426}.