LMPD Database

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LMP003096

UniProt Annotations

Entry Information
Gene Namephospholipase A2, activating protein
Protein EntryPLAP_MOUSE
UniProt IDP27612
SpeciesMouse
Comments
Comment typeDescription
DomainThe PFU domain mediates interaction with ubiquitin. {ECO:0000250}.
DomainThe PUL domain is composed of 6 armadillo-like repeats and mediates the interaction with VCP C-terminus. {ECO:0000250}.
FunctionInvolved in the maintenance of ubiquitin levels. {ECO:0000250}.
InductionIn smooth muscle and endothelial cells by leukotriene D4, by tumor necrosis factor in endothelial cells and by uric acid crystals in macrophages.
Sequence CautionSequence=AAA39943.1; Type=Miscellaneous discrepancy; Note=Several frameshifts and contaminating sequence.; Evidence={ECO:0000305}; Sequence=Ref.3; Type=Frameshift; Positions=697; Evidence={ECO:0000305};
SimilarityBelongs to the WD repeat PLAP family. {ECO:0000305}.
SimilarityContains 1 PFU domain. {ECO:0000255|PROSITE- ProRule:PRU00727}.
SimilarityContains 1 PUL domain. {ECO:0000255|PROSITE- ProRule:PRU00729}.
SimilarityContains 6 ARM repeats. {ECO:0000305}.
SimilarityContains 7 WD repeats. {ECO:0000255|PROSITE- ProRule:PRU00221}.
SubunitInteracts with ubiquitin. Interacts with VCP (By similarity). {ECO:0000250}.