LMPD Database

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LMP003007

UniProt Annotations

Entry Information
Gene Nameglycerophosphodiester phosphodiesterase domain containing 5
Protein EntryGDPD5_MOUSE
UniProt IDQ640M6
SpeciesMouse
Comments
Comment typeDescription
FunctionPromotes neurite formation. Cooperates with PRDX1 to drive postmitotic motor neuron differentiation. The glycerophosphodiester phosphodiesterase activity may be required for its role in neuronal differentiation. May contribute to the osmotic regulation of cellular glycerophosphocholine. {ECO:0000269|PubMed:17275818, ECO:0000269|PubMed:18667693}.
InductionUp-regulated during neuronal differentiation by retinoic acid. {ECO:0000269|PubMed:17275818}.
PtmIntramolecular disulfide bond between Cys-25 and Cys-571 is reduced by PRDX1. {ECO:0000250}.
Sequence CautionSequence=AAH26428.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the glycerophosphoryl diester phosphodiesterase family. {ECO:0000305}.
SimilarityContains 1 GP-PDE domain. {ECO:0000305}.
Subcellular LocationEndomembrane system {ECO:0000305}; Multi- pass membrane protein {ECO:0000305}. Cytoplasm, perinuclear region. Cell projection, growth cone. Note=In a punctate perinuclear pattern.
SubunitInteracts with PRDX1; forms a mixed-disulfide with PRDX1, leading to disrupt intramolecular disulfide bond between Cys-25 and Cys-571. {ECO:0000250}.
Tissue SpecificityDetected in brain, lung, heart, kidney and testis. {ECO:0000269|PubMed:15276213}.