LMPD Database

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LMP003004

UniProt Annotations

Entry Information
Gene Namesolute carrier family 18 (vesicular monoamine), member 2
Protein EntryVMAT2_MOUSE
UniProt IDQ8BRU6
SpeciesMouse
Comments
Comment typeDescription
FunctionInvolved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis (By similarity). {ECO:0000250}.
SimilarityBelongs to the major facilitator superfamily. Vesicular transporter family. {ECO:0000305}.
Subcellular LocationCytoplasmic vesicle membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
SubunitInteracts with SLC6A3. {ECO:0000269|PubMed:19357284}.