LMPD Database

LMP002984

Gene Information

Entrez Gene ID	6469
Gene Name	sonic hedgehog
Gene Symbol	SHH
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0009986	ISS:UniProtKB	C	cell surface
GO:0031012	IEA:Ensembl	C	extracellular matrix
GO:0005615	IDA:UniProtKB	C	extracellular space
GO:0045121	ISS:UniProtKB	C	membrane raft
GO:0005634	IEA:Ensembl	C	nucleus
GO:0005886	IEA:UniProtKB-KW	C	plasma membrane
GO:0005509	IDA:UniProtKB	F	calcium ion binding
GO:0005539	IEA:Ensembl	F	glycosaminoglycan binding
GO:0043237	ISS:UniProtKB	F	laminin-1 binding
GO:0016015	NAS:BHF-UCL	F	morphogen activity
GO:0005113	IDA:BHF-UCL	F	patched binding
GO:0008233	IEA:UniProtKB-KW	F	peptidase activity
GO:0008270	IDA:UniProtKB	F	zinc ion binding
GO:0008209	ISS:UniProtKB	P	androgen metabolic process
GO:0097190	ISS:UniProt	P	apoptotic signaling pathway
GO:0060840	IEA:Ensembl	P	artery development
GO:0007411	ISS:UniProtKB	P	axon guidance
GO:0060020	IEA:Ensembl	P	Bergmann glial cell differentiation
GO:0007596	IEA:Ensembl	P	blood coagulation
GO:0060445	IEA:Ensembl	P	branching involved in salivary gland morphogenesis
GO:0001658	ISS:UniProtKB	P	branching involved in ureteric bud morphogenesis
GO:0048754	ISS:UniProtKB	P	branching morphogenesis of an epithelial tube
GO:0060447	IEA:Ensembl	P	bud outgrowth involved in lung branching
GO:0043010	IEA:Ensembl	P	camera-type eye development
GO:0060070	IEA:Ensembl	P	canonical Wnt signaling pathway
GO:0043369	IDA:BHF-UCL	P	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment
GO:0007267	ISS:UniProtKB	P	cell-cell signaling
GO:0048468	ISS:UniProtKB	P	cell development
GO:0001708	ISS:UniProtKB	P	cell fate specification
GO:0071285	IEA:Ensembl	P	cellular response to lithium ion
GO:0007417	ISS:UniProtKB	P	central nervous system development
GO:0021930	ISS:UniProtKB	P	cerebellar granule cell precursor proliferation
GO:0003140	ISS:BHF-UCL	P	determination of left/right asymmetry in lateral mesoderm
GO:0021904	IEA:Ensembl	P	dorsal/ventral neural tube patterning
GO:0009953	ISS:UniProtKB	P	dorsal/ventral pattern formation
GO:0007398	IEA:Ensembl	P	ectoderm development
GO:0009790	ISS:UniProtKB	P	embryo development
GO:0048557	IEA:Ensembl	P	embryonic digestive tract morphogenesis
GO:0042733	ISS:UniProtKB	P	embryonic digit morphogenesis
GO:0048617	IEA:Ensembl	P	embryonic foregut morphogenesis
GO:0035115	IEA:Ensembl	P	embryonic forelimb morphogenesis
GO:0035116	IEA:Ensembl	P	embryonic hindlimb morphogenesis
GO:0030326	ISS:UniProtKB	P	embryonic limb morphogenesis
GO:0009880	TAS:BHF-UCL	P	embryonic pattern specification
GO:0048706	IEA:Ensembl	P	embryonic skeletal system development
GO:0006897	IEA:Ensembl	P	endocytosis
GO:0060664	IEA:Ensembl	P	epithelial cell proliferation involved in salivary gland morphogenesis
GO:0060738	IDA:MGI	P	epithelial-mesenchymal signaling involved in prostate gland development
GO:0030010	IEA:Ensembl	P	establishment of cell polarity
GO:0030900	ISS:UniProtKB	P	forebrain development
GO:0048859	IEA:Ensembl	P	formation of anatomical boundary
GO:0031069	IEA:Ensembl	P	hair follicle morphogenesis
GO:0007507	ISS:UniProtKB	P	heart development
GO:0001947	ISS:BHF-UCL	P	heart looping
GO:0030902	ISS:UniProtKB	P	hindbrain development
GO:0007442	IEA:Ensembl	P	hindgut morphogenesis
GO:0048839	IEA:Ensembl	P	inner ear development
GO:0016539	IEA:InterPro	P	intein-mediated protein splicing
GO:0045109	IEA:Ensembl	P	intermediate filament organization
GO:0060459	IEA:Ensembl	P	left lung development
GO:0060174	IEA:Ensembl	P	limb bud formation
GO:0060484	IEA:Ensembl	P	lung-associated mesenchyme development
GO:0030324	ISS:UniProtKB	P	lung development
GO:0060428	IEA:Ensembl	P	lung epithelium development
GO:0060463	IEA:Ensembl	P	lung lobe morphogenesis
GO:0002320	IMP:BHF-UCL	P	lymphoid progenitor cell differentiation
GO:0030539	ISS:UniProtKB	P	male genitalia development
GO:0060916	IEA:Ensembl	P	mesenchymal cell proliferation involved in lung development
GO:0060783	IEA:Ensembl	P	mesenchymal smoothened signaling pathway involved in prostate gland development
GO:0072136	ISS:UniProtKB	P	metanephric mesenchymal cell proliferation involved in metanephros development
GO:0001656	ISS:UniProtKB	P	metanephros development
GO:0030901	ISS:UniProtKB	P	midbrain development
GO:0080125	IEA:Ensembl	P	multicellular structure septum development
GO:0045445	IEA:Ensembl	P	myoblast differentiation
GO:0014902	IEA:Ensembl	P	myotube differentiation
GO:0046639	IEA:Ensembl	P	negative regulation of alpha-beta T cell differentiation
GO:0043066	ISS:UniProt	P	negative regulation of apoptotic process
GO:0090090	IEA:Ensembl	P	negative regulation of canonical Wnt signaling pathway
GO:0045596	ISS:UniProtKB	P	negative regulation of cell differentiation
GO:0030336	ISS:UniProtKB	P	negative regulation of cell migration
GO:0090370	ISS:BHF-UCL	P	negative regulation of cholesterol efflux
GO:2000357	ISS:UniProtKB	P	negative regulation of kidney smooth muscle cell differentiation
GO:2001054	IEA:Ensembl	P	negative regulation of mesenchymal cell apoptotic process
GO:0032435	IEA:Ensembl	P	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0042130	IEA:Ensembl	P	negative regulation of T cell proliferation
GO:0034244	IEA:Ensembl	P	negative regulation of transcription elongation from RNA polymerase II promoter
GO:0000122	ISS:BHF-UCL	P	negative regulation of transcription from RNA polymerase II promoter
GO:2000062	ISS:UniProtKB	P	negative regulation of ureter smooth muscle cell differentiation
GO:0045060	ISS:UniProtKB	P	negative thymic T cell selection
GO:0001755	ISS:UniProtKB	P	neural crest cell migration
GO:0007405	ISS:UniProtKB	P	neuroblast proliferation
GO:0048663	ISS:UniProtKB	P	neuron fate commitment
GO:0042475	IEA:Ensembl	P	odontogenesis of dentin-containing tooth
GO:0014003	IEA:Ensembl	P	oligodendrocyte development
GO:0048645	IEA:Ensembl	P	organ formation
GO:0002076	IEA:Ensembl	P	osteoblast development
GO:0060021	IEA:Ensembl	P	palate development
GO:0031016	IEA:Ensembl	P	pancreas development
GO:0001569	ISS:UniProtKB	P	patterning of blood vessels
GO:0007389	ISS:UniProtKB	P	pattern specification process
GO:0009949	ISS:UniProt	P	polarity specification of anterior/posterior axis
GO:0046638	ISS:UniProtKB	P	positive regulation of alpha-beta T cell differentiation
GO:0051781	IDA:BHF-UCL	P	positive regulation of cell division
GO:0008284	ISS:UniProtKB	P	positive regulation of cell proliferation
GO:0060769	IEA:Ensembl	P	positive regulation of epithelial cell proliferation involved in prostate gland development
GO:0007228	ISS:BHF-UCL	P	positive regulation of hh target transcription factor activity
GO:0033092	ISS:BHF-UCL	P	positive regulation of immature T cell proliferation in thymus
GO:2000358	ISS:UniProtKB	P	positive regulation of kidney smooth muscle cell differentiation
GO:2000729	ISS:UniProtKB	P	positive regulation of mesenchymal cell proliferation involved in ureter development
GO:0002052	IEA:Ensembl	P	positive regulation of neuroblast proliferation
GO:0048714	IEA:Ensembl	P	positive regulation of oligodendrocyte differentiation
GO:0042307	IEA:Ensembl	P	positive regulation of protein import into nucleus
GO:0061189	IDA:BHF-UCL	P	positive regulation of sclerotome development
GO:0014858	IEA:Ensembl	P	positive regulation of skeletal muscle cell proliferation
GO:0048643	IEA:Ensembl	P	positive regulation of skeletal muscle tissue development
GO:0045880	IDA:UniProtKB	P	positive regulation of smoothened signaling pathway
GO:0051155	IEA:Ensembl	P	positive regulation of striated muscle cell differentiation
GO:0033089	ISS:UniProtKB	P	positive regulation of T cell differentiation in thymus
GO:0045893	IDA:BHF-UCL	P	positive regulation of transcription, DNA-templated
GO:0045944	ISS:BHF-UCL	P	positive regulation of transcription from RNA polymerase II promoter
GO:2000063	ISS:UniProtKB	P	positive regulation of ureter smooth muscle cell differentiation
GO:0030177	IEA:Ensembl	P	positive regulation of Wnt signaling pathway
GO:0045059	ISS:UniProtKB	P	positive thymic T cell selection
GO:0060516	IEA:Ensembl	P	primary prostatic bud elongation
GO:0060523	IEA:Ensembl	P	prostate epithelial cord elongation
GO:0030850	ISS:UniProtKB	P	prostate gland development
GO:0034504	IEA:Ensembl	P	protein localization to nucleus
GO:0042127	ISS:UniProtKB	P	regulation of cell proliferation
GO:0060782	IEA:Ensembl	P	regulation of mesenchymal cell proliferation involved in prostate gland development
GO:1900175	NAS:BHF-UCL	P	regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
GO:0042481	ISS:BHF-UCL	P	regulation of odontogenesis
GO:0060685	IEA:Ensembl	P	regulation of prostatic bud formation
GO:1900180	IDA:BHF-UCL	P	regulation of protein localization to nucleus
GO:0030162	ISS:UniProtKB	P	regulation of proteolysis
GO:0072001	IEP:UniProtKB	P	renal system development
GO:0060458	IEA:Ensembl	P	right lung development
GO:0060662	IEA:Ensembl	P	salivary gland cavitation
GO:0007224	IEP:UniProtKB	P	smoothened signaling pathway
GO:0021938	IEA:Ensembl	P	smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
GO:0061053	ISS:BHF-UCL	P	somite development
GO:0021513	IEA:Ensembl	P	spinal cord dorsal/ventral patterning
GO:0021522	IEA:Ensembl	P	spinal cord motor neuron differentiation
GO:0048864	ISS:UniProtKB	P	stem cell development
GO:0014706	IEA:Ensembl	P	striated muscle tissue development
GO:0033077	ISS:BHF-UCL	P	T cell differentiation in thymus
GO:0021978	IEA:Ensembl	P	telencephalon regionalization
GO:0021794	IEA:Ensembl	P	thalamus development
GO:0048538	ISS:UniProtKB	P	thymus development
GO:0030878	IEA:Ensembl	P	thyroid gland development
GO:0060439	IEA:Ensembl	P	trachea morphogenesis
GO:0001570	ISS:UniProtKB	P	vasculogenesis
GO:0007418	TAS:BHF-UCL	P	ventral midline development

KEGG Pathway Links

KEGG Pathway ID	Description
hsa05217	Basal cell carcinoma
hsa04340	Hedgehog signaling pathway