LMPD Database

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LMP002979

UniProt Annotations

Entry Information
Gene Namephosphatidic acid phosphatase type 2 domain containing 2
Protein EntryPPAC2_HUMAN
UniProt IDQ8IY26
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiespH dependence: Optimum pH is 7-8. ;
FunctionPhosphatase that dephosphorylates presqualene diphosphate (PSDP) into presqualene monophosphate (PSMP), suggesting that it may be indirectly involved in innate immunity. PSDP is a bioactive lipid that rapidly remodels to presqualene monophosphate PSMP upon cell activation. Displays diphosphate phosphatase activity with a substrate preference for PSDP > FDP > phosphatidic acid.
Sequence CautionSequence=AK074672; Type=Frameshift; Positions=267; Evidence= ;
SimilarityBelongs to the PA-phosphatase related phosphoesterase family.
Subcellular LocationMembrane ; Multi-pass membrane protein .
Tissue SpecificityWidely expressed. Expressed in most organs, in particular gastrointestinal organs, spleen, placenta, kidney, thymus and brain.