LMPD Database

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LMP002974

UniProt Annotations

Entry Information
Gene Namephosphatidylinositol-4-phosphate 5-kinase, type 1 beta
Protein EntryPI51B_MOUSE
UniProt IDP70181
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P70181-1; Sequence=Displayed; Name=2; IsoId=P70181-2; Sequence=VSP_016012; Note=No experimental confirmation available.;
Biophysicochemical PropertiesKinetic parameters: KM=34 uM for PtdIns(4)P {ECO:0000269|PubMed:9535851}; KM=27 uM for ATP {ECO:0000269|PubMed:9535851};
Catalytic ActivityATP + 1-phosphatidyl-1D-myo-inositol 4- phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.
CautionThere is confusion in the literature with phosphatidylinositol 4-phosphate 5-kinase type I nomenclature due to the fact that frequently mouse PIP5K1B is named Phosphatidylinositol 4-phosphate 5-kinase type I alpha. {ECO:0000305}.
Enzyme RegulationActivated by phosphatidic acid. {ECO:0000269|PubMed:8798574, ECO:0000269|PubMed:9535851}.
FunctionParticipates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of PLD2. Together with PIP5K1A is required after stimulation of G-protein coupled receptors for stable platelet adhesion. {ECO:0000269|PubMed:10679324, ECO:0000269|PubMed:18772378, ECO:0000269|PubMed:8798574}.
InteractionQ9QYB1:Clic4; NbExp=4; IntAct=EBI-645167, EBI-645175;
SimilarityContains 1 PIPK domain. {ECO:0000255|PROSITE- ProRule:PRU00781}.
Subcellular LocationEndomembrane system {ECO:0000250}. Note=Associated with membranes. {ECO:0000250}.
SubunitInteracts with RAC1, AJUBA, PLD1, PLD2 and ARF1. {ECO:0000269|PubMed:10679324, ECO:0000269|PubMed:10747863, ECO:0000269|PubMed:11032811, ECO:0000269|PubMed:15870270}.
Tissue SpecificityHighly expressed in brain and testis. Barely detectable in liver and skeletal muscle. {ECO:0000269|PubMed:8798574}.