LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP002954

UniProt Annotations

Entry Information
Gene Namesterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae)
Protein EntrySC5D_MOUSE
UniProt IDO88822
SpeciesMouse
Comments
Comment typeDescription
Catalytic Activity5-alpha-cholest-7-en-3-beta-ol + NAD(P)H + O(2) = cholesta-5,7-dien-3-beta-ol + NAD(P)(+) + 2 H(2)O.
CofactorName=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence={ECO:0000250};
DomainThe histidine box domains may contain the active site and/or be involved in metal ion binding.
FunctionCatalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol.
SimilarityBelongs to the sterol desaturase family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.