LMPD Database

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LMP002951

UniProt Annotations

Entry Information
Gene Namenuclear receptor subfamily 5, group A, member 2
Protein EntryNR5A2_HUMAN
UniProt IDO00482
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=2; Synonyms=B1F2; IsoId=O00482-1; Sequence=Displayed; Name=1; IsoId=O00482-2; Sequence=VSP_003716; Name=3; IsoId=O00482-3; Sequence=VSP_003717; Note=Does not induce CYP7A promoter activity.; Name=4; IsoId=O00482-4; Sequence=VSP_054548; Note=No experimental confirmation available.;
FunctionBinds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.
InteractionO60869:EDF1; NbExp=2; IntAct=EBI-781320, EBI-781301; Q92786:PROX1; NbExp=9; IntAct=EBI-9257474, EBI-3912635;
SimilarityBelongs to the nuclear hormone receptor family. NR5 subfamily.
SimilarityContains 1 nuclear receptor DNA-binding domain.
Subcellular LocationNucleus .
SubunitBinds DNA as a monomer (By similarity). Interacts with GRIP1, NCOA2 and NR0B2. {ECO
Tissue SpecificityAbundantly expressed in pancreas, less in liver, very low levels in heart and lung. Expressed in the Hep-G2 cell line. Isoform 1 and isoform 2 seem to be present in fetal and adult liver and Hep-G2 cells.