LMPD Database

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LMP002947

UniProt Annotations

Entry Information
Gene NameUDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
Protein EntryB4GT2_HUMAN
UniProt IDO60909
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=O60909-1; Sequence=Displayed; Name=2; IsoId=O60909-2; Sequence=VSP_014103, VSP_014104; Note=No experimental confirmation available.; Name=3; IsoId=O60909-3; Sequence=VSP_043010; Note=No experimental confirmation available.;
Biophysicochemical PropertiesKinetic parameters: KM=71 uM for GlcNAc-B-S-pNP ;
Catalytic ActivityUDP-alpha-D-galactose + D-glucose = UDP + lactose.
Catalytic ActivityUDP-alpha-D-galactose + N-acetyl-beta-D- glucosaminylglycopeptide = UDP + beta-D-galactosyl-(1->4)-N- acetyl-beta-D-glucosaminylglycopeptide.
Catalytic ActivityUDP-alpha-D-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine.
CofactorName=Mn(2+); Xref=ChEBI
FunctionResponsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. Can produce lactose.
PathwayProtein modification; protein glycosylation.
SimilarityBelongs to the glycosyltransferase 7 family.
Subcellular LocationGolgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Trans cisternae of Golgi stack.
Tissue SpecificityWeakly expressed in various tissues. Highest expression in prostate, testis, ovary, intestine, muscle, and in fetal brain.
Web ResourceName=Functional Glycomics Gateway - GTase; Note=Beta-1,4-galactosyltransferase 2; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_437";
Web ResourceName=GGDB; Note=GlycoGene database; URL="http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=B4GALT2";