LMPD Database

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LMP002907

UniProt Annotations

Entry Information
Gene Namebeta-1,4-N-acetyl-galactosaminyl transferase 1
Protein EntryQ3UN35_MOUSE
UniProt IDQ3UN35
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityUDP-N-acetyl-alpha-D-galactosamine + O-(N- acetyl-alpha-neuraminyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)- beta-D-glucopyranosyl-(1<->1)-ceramide = UDP + O-2-(acetylamino)- 2-deoxy-beta-D-galactopyranosyl-(1->4)-O-(N-acetyl-alpha- neuraminyl-(2->3))-O-beta-D-galactopyranosyl-(1->4)-beta-D- glucopyranosyl-(1<->1)-ceramide.
Developmental StageHighest at day 7 of embryonic development after which it declines to its lowest levels at day 11 before increasing again.
FunctionInvolved in the biosynthesis of gangliosides GM2, GD2 and GA2.
PathwayProtein modification; protein glycosylation.
SimilarityBelongs to the glycosyltransferase 2 family. {ECO:0000305}.
Subcellular LocationGolgi apparatus membrane; Single-pass type II membrane protein.
SubunitHomodimer; disulfide-linked. {ECO:0000250}.
Tissue SpecificityMost abundant in brain, liver, lung, spleen and testis.
Web ResourceName=Functional Glycomics Gateway - GTase; Note=Beta-1,4 N-acetylgalactosaminyltransferase 1; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_506";