LMPD Database

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LMP002873

UniProt Annotations

Entry Information
Gene Namepalmitoyl-protein thioesterase 2
Protein EntryPPT2_MOUSE
UniProt IDO35448
SpeciesMouse
Comments
Comment typeDescription
Disruption PhenotypeMice are healthy at birth, but develop neuronal abnormalities, infiltration of bone marrow by macrophages and multinucleated giant cells, and splenomegaly caused by extramedullary hematopoiesis. Autofluorescent storage material is present in many cell types, particularly reticuloendothelial cells and neurons. {ECO:0000269|PubMed:11717424, ECO:0000269|PubMed:14528005}.
FunctionRemoves thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S- thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins (By similarity). {ECO:0000250}.
SimilarityBelongs to the palmitoyl-protein thioesterase family. {ECO:0000305}.
Subcellular LocationLysosome {ECO:0000269|PubMed:14528005}.
Tissue SpecificityExpressed throughout the brain, primarily in neurons, and at lower levels in glial cells. {ECO:0000269|PubMed:11717424, ECO:0000269|PubMed:14528005}.