LMPD Database

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LMP002864

UniProt Annotations

Entry Information
Gene Nameprostaglandin I receptor (IP)
Protein EntryPI2R_MOUSE
UniProt IDP43252
SpeciesMouse
Comments
Comment typeDescription
FunctionReceptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.
PtmIsoprenylation does not influence ligand binding but is required for efficient coupling to the effectors adenylyl cyclase and phospholipase C. {ECO:0000269|PubMed:10446129}.
Sequence CautionSequence=BAA05144.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}.
Subcellular LocationCell membrane; Multi-pass membrane protein.
SubunitInteracts (non-isoprenylated C-terminus) with PDZK1. {ECO:0000269|PubMed:23457445}.