LMPD Database

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LMP002863

UniProt Annotations

Entry Information
Gene Namebiotinidase
Protein EntryP43251_HUMAN
UniProt IDP43251
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=P43251-1; Sequence=Displayed; Name=2; IsoId=P43251-2; Sequence=VSP_054925; Note=No experimental confirmation available.; Name=3; IsoId=P43251-3; Sequence=VSP_054926; Note=No experimental confirmation available.; Name=4; IsoId=P43251-4; Sequence=VSP_055921; Note=No experimental confirmation available.;
Catalytic ActivityBiotin amide + H(2)O = biotin + NH(3).
CautionIt is uncertain whether Met-1 or Met-21 is the initiator.
DiseaseBiotinidase deficiency (BTD deficiency) [MIM
FunctionCatalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation.
SimilarityBelongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.
SimilarityContains 1 CN hydrolase domain. {ECO
Subcellular LocationSecreted, extracellular space.