LMPD Database

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LMP002861

UniProt Annotations

Entry Information
Gene NameG protein-coupled receptor kinase 6
Protein EntryGRK6_HUMAN
UniProt IDP43250
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=GRK6A; IsoId=P43250-1; Sequence=Displayed; Name=GRK6B; IsoId=P43250-2; Sequence=VSP_004938; Name=GRK6C; IsoId=P43250-3; Sequence=VSP_041813, VSP_041814;
Catalytic ActivityATP + [G-protein-coupled receptor] = ADP + [G- protein-coupled receptor] phosphate.
FunctionSpecifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro). {ECO
InteractionP52205:ROM1 (xeno); NbExp=9; IntAct=EBI-722747, EBI-8176947;
PtmIt is uncertain whether palmitoylation is on Cys-561 and/or Cys-562 and/or Cys-565.
SimilarityBelongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
SimilarityContains 1 AGC-kinase C-terminal domain.
SimilarityContains 1 protein kinase domain.
SimilarityContains 1 RGS domain. {ECO
Subcellular LocationMembrane; Lipid-anchor.
Tissue SpecificityWidely expressed.