LMPD Database

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LMP002856

UniProt Annotations

Entry Information
Gene Name3-oxoacid CoA transferase 1
Protein EntrySCOT1_MOUSE
UniProt IDQ9D0K2
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivitySuccinyl-CoA + a 3-oxo acid = succinate + a 3- oxoacyl-CoA. {ECO:0000255|PROSITE-ProRule:PRU10034}.
FunctionKey enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity). {ECO:0000250}.
PathwayKetone metabolism; succinyl-CoA degradation; acetoacetyl- CoA from succinyl-CoA: step 1/1.
SimilarityBelongs to the 3-oxoacid CoA-transferase family. {ECO:0000305}.
Subcellular LocationMitochondrion matrix {ECO:0000250}.
SubunitHomodimer. {ECO:0000250}.