LMPD Database

LMP002843

Gene Information

Entrez Gene ID	6609
Gene Name	sphingomyelin phosphodiesterase 1, acid lysosomal
Gene Symbol	SMPD1
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005615	IEA:Ensembl	C	extracellular space
GO:0070062	IDA:UniProtKB	C	extracellular vesicular exosome
GO:0042599	IEA:Ensembl	C	lamellar body
GO:0043202	TAS:Reactome	C	lysosomal lumen
GO:0016798	IEA:UniProtKB-KW	F	hydrolase activity, acting on glycosyl bonds
GO:0004767	TAS:ProtInc	F	sphingomyelin phosphodiesterase activity
GO:0008219	IEA:UniProtKB-KW	P	cell death
GO:0046513	IMP:BHF-UCL	P	ceramide biosynthetic process
GO:0006687	TAS:Reactome	P	glycosphingolipid metabolic process
GO:0043407	IMP:BHF-UCL	P	negative regulation of MAP kinase activity
GO:0007399	TAS:ProtInc	P	nervous system development
GO:0043065	IEA:Ensembl	P	positive regulation of apoptotic process
GO:0035307	IMP:BHF-UCL	P	positive regulation of protein dephosphorylation
GO:0042220	IEA:Ensembl	P	response to cocaine
GO:0042493	IEA:Ensembl	P	response to drug
GO:0007165	TAS:ProtInc	P	signal transduction
GO:0044281	TAS:Reactome	P	small molecule metabolic process
GO:0006665	TAS:Reactome	P	sphingolipid metabolic process
GO:0006685	IEA:InterPro	P	sphingomyelin catabolic process
GO:0006684	TAS:ProtInc	P	sphingomyelin metabolic process
GO:0023021	IMP:BHF-UCL	P	termination of signal transduction

KEGG Pathway Links

KEGG Pathway ID	Description
hsa04142	Lysosome

BIOCYC Pathway Links

BIOCYC Pathway ID	Description
PWY3DJ-11281	sphingomyelin metabolism

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_116105	Glycosphingolipid metabolism