LMPD Database

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LMP002839

UniProt Annotations

Entry Information
Gene Nameperoxisome proliferative activated receptor, gamma, coactivator 1 alpha
Protein EntryPRGC1_MOUSE
UniProt IDO70343
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative promoter usage, Alternative splicing; Named isoforms=4; Name=1; Synonyms=PGC-1a1; IsoId=O70343-1; Sequence=Displayed; Name=2; Synonyms=PGC-1a2; IsoId=O70343-2; Sequence=VSP_053275, VSP_053277, VSP_053278, VSP_053280; Note=Produced by alternative promoter usage and alternative splicing.; Name=3; Synonyms=PGC-1a3; IsoId=O70343-3; Sequence=VSP_053276, VSP_053277, VSP_053278, VSP_053280; Note=Produced by alternative promoter usage and alternative splicing.; Name=4; Synonyms=PGC-1a4; IsoId=O70343-4; Sequence=VSP_053275, VSP_053279, VSP_053281; Note=Produced by alternative promoter usage and alternative splicing.;
Disruption PhenotypeMice show abnormal diurnal rhythms of activity, body temperature and metabolic rate. {ECO:0000269|PubMed:17476214}.
FunctionTranscriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK. Isoform 4 specifically activates the expression of IGF1 and suppresses myostatin expression in skeletal muscle leading to muscle fiber hypertrophy. {ECO:0000269|PubMed:15744310, ECO:0000269|PubMed:17476214, ECO:0000269|PubMed:23217713, ECO:0000269|PubMed:9529258}.
InductionDramatically induced in brown adipose tissue and skeletal muscle by exposure of animals to cold. Up-regulated in brown adipose tissue of obese leptin-deficient (ob/ob) and leptin- unresponsive (db/db) mice. Leptin is required for normal basal and cold-stimulated expression in brown adipose tissue and hyperleptinemia rapidly up-regulates its expression. Induced in muscle by exercise. Oscillates diurnally in liver and skeletal muscle. {ECO:0000269|PubMed:11108270, ECO:0000269|PubMed:17476214, ECO:0000269|PubMed:22237023, ECO:0000269|PubMed:23217713, ECO:0000269|PubMed:9529258}.
InteractionQ6PB66:Lrpprc; NbExp=2; IntAct=EBI-1371053, EBI-1371262; Q923E4:Sirt1; NbExp=6; IntAct=EBI-1371053, EBI-1802585;
PtmHeavily acetylated by GCN5 and biologically inactive under conditions of high nutrients. Deacetylated by SIRT1 in low nutrients/high NAD conditions. {ECO:0000269|PubMed:15744310}.
PtmPhosphorylation by AMPK in skeletal muscle increases activation of its own promoter. Phosphorylated by CLK2. {ECO:0000269|PubMed:17609368, ECO:0000269|PubMed:20074525}.
PtmUbiquitinated. Ubiquitination by RNF34 induces proteasomal degradation. {ECO:0000250|UniProtKB:Q9UBK2}.
SimilarityContains 1 RRM (RNA recognition motif) domain. {ECO:0000255|PROSITE-ProRule:PRU00176}.
Subcellular LocationNucleus. Nucleus, PML body.
SubunitHomooligomer (By similarity). Interacts with MYBBP1A; inhibits MYBBP1A transcriptional activation. Interacts with PRDM16, LPIN1 and PML. Interacts (via LXXLL motif) with RORA and RORC (via AF-2 motif); activates RORA and RORC transcriptional activation. Interacts with LRPPRC (By similarity). Interacts with RNF34 (via RING-type zinc finger) (By similarity). {ECO:0000250|UniProtKB:Q9UBK2, ECO:0000269|PubMed:14744933, ECO:0000269|PubMed:16950137, ECO:0000269|PubMed:17476214, ECO:0000269|PubMed:17618855, ECO:0000269|PubMed:18483224, ECO:0000269|PubMed:22886304}.
Tissue SpecificityWhite quadriceps and red tibialis anterior (TA) muscles, liver, kidney and brown adipose tissue (at protein level). Skeletal muscle, brown adipose tissue, heart, kidney and brain. {ECO:0000269|PubMed:17476214, ECO:0000269|PubMed:23217713, ECO:0000269|PubMed:9529258}.