LMPD Database

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LMP002797

UniProt Annotations

Entry Information
Gene Namehematopoietic prostaglandin D synthase
Protein EntryHPGDS_MOUSE
UniProt IDQ9JHF7
SpeciesMouse
Comments
Comment typeDescription
Catalytic Activity(5Z,13E,15S)-9-alpha,11-alpha-epidioxy-15- hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-9-alpha,15-dihydroxy- 11-oxoprosta-5,13-dienoate. {ECO:0000269|PubMed:10824118}.
Catalytic ActivityRX + glutathione = HX + R-S-glutathione. {ECO:0000269|PubMed:10824118}.
CofactorName=glutathione; Xref=ChEBI:CHEBI:57925; Evidence={ECO:0000269|PubMed:10824118}; Note=Glutathione is required for the prostaglandin D synthase activity. {ECO:0000269|PubMed:10824118};
FunctionBifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity. {ECO:0000269|PubMed:10824118, ECO:0000269|PubMed:16547010}.
SimilarityBelongs to the GST superfamily. Sigma family. {ECO:0000305}.
SimilarityContains 1 GST C-terminal domain. {ECO:0000305}.
SimilarityContains 1 GST N-terminal domain. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitHomodimer. {ECO:0000250}.
Tissue SpecificityExpressed in skin and oviduct. {ECO:0000269|PubMed:10824118}.