LMPD Database

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LMP002772

UniProt Annotations

Entry Information
Gene NameUDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
Protein EntryB3GT4_MOUSE
UniProt IDQ9Z0F0
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityUDP-alpha-D-galactose + an N-acetyl-beta-D- galactosaminyl-(1->4)-(alpha-N-acetylneuraminyl-(2->3))-beta-D- galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + a beta- D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-(alpha- N-acetylneuraminyl-(2->3))-beta-D-galactosyl-(1->4)-beta-D- glucosyl-(1<->1)-ceramide.
Developmental StageFirst expressed at embryonic day 3. Maintained at high levels between days 4 and 7 and declines thereafter to stabilize at low levels after day 10. {ECO:0000269|PubMed:10502288}.
FunctionInvolved in GM1/GD1B/GA1 ganglioside biosynthesis. {ECO:0000269|PubMed:10502288}.
PathwayProtein modification; protein glycosylation.
SimilarityBelongs to the glycosyltransferase 31 family. {ECO:0000305}.
Subcellular LocationGolgi apparatus membrane; Single-pass type II membrane protein.
Tissue SpecificityExpressed in heart, brain, spleen, kidney, lung and testis. {ECO:0000269|PubMed:10502288}.
Web ResourceName=Functional Glycomics Gateway - GTase; Note=b3GalT4; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_457";