LMPD Database

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LMP002745

UniProt Annotations

Entry Information
Gene Namesulfotransferase family, cytosolic, 2B, member 1
Protein EntryST2B1_MOUSE
UniProt IDO35400
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; Synonyms=SULT2B1b, B; IsoId=O35400-1; Sequence=Displayed; Name=2; Synonyms=SULT2B1a, A; IsoId=O35400-2; Sequence=VSP_012511; Note=No experimental confirmation available.;
Catalytic Activity3'-phosphoadenylyl sulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate.
Developmental StageIsoform 1 and isoform 2 are expressed from stages E8.5-E19 embryo. {ECO:0000269|PubMed:12639899}.
FunctionSulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids such as dehydroepiandrosterone. Isoform 1 is required for production of cholesterol sulfate essential for normal skin development whereas isoform 2 produces pregnenolone sulfate, an essential neurosteroid during development of the central nervous system.
SimilarityBelongs to the sulfotransferase 1 family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000250}. Microsome {ECO:0000250}.
Tissue SpecificityExpressed at high levels in epididymis, intestine and uterus, and low levels in brain and hypothalamus. Isoform 2 is most prominent in the brain and spinal cord, with modest expression in the lung, skin and spleen. Isoform 1 is most prominently expressed in skin and small intestine, with modest expression in muscle and prostate. {ECO:0000269|PubMed:12639899, ECO:0000269|PubMed:9647753}.