LMPD Database

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LMP002742

UniProt Annotations

Entry Information
Gene Namediacylglycerol kinase, theta
Protein EntryDGKQ_MOUSE
UniProt IDQ6P5E8
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6P5E8-1; Sequence=Displayed; Name=2; IsoId=Q6P5E8-2; Sequence=VSP_037832; Note=No experimental confirmation available.;
Catalytic ActivityATP + 1,2-diacyl-sn-glycerol = ADP + 1,2- diacyl-sn-glycerol 3-phosphate.
Enzyme RegulationInactivated by binding to RHOA. Not inhibited by phosphatidylserine (By similarity). {ECO:0000250}.
FunctionPhosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). May regulate the activity of protein kinase C by controlling the balance between these two signaling lipids. Activated in the nucleus in response to alpha-thrombin and nerve growth factor (By similarity). May be involved in cAMP- induced activation of NR5A1 and subsequent steroidogenic gene transcription by delivering PA as ligand for NR5A1. Acts synergistically with NR5A1 on CYP17 transcriptional activity (By similarity). {ECO:0000250}.
PtmPhosphorylated by PRKCE and PRKCH in vitro. {ECO:0000250}.
SimilarityBelongs to the eukaryotic diacylglycerol kinase family. {ECO:0000305}.
SimilarityContains 1 DAGKc domain. {ECO:0000255|PROSITE- ProRule:PRU00783}.
SimilarityContains 1 Ras-associating domain. {ECO:0000255|PROSITE-ProRule:PRU00166}.
SimilarityContains 3 phorbol-ester/DAG-type zinc fingers. {ECO:0000255|PROSITE-ProRule:PRU00226}.
Subcellular LocationCytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus {ECO:0000250}. Nucleus speckle {ECO:0000250}. Note=Translocates to the nucleus in response to thrombin stimulation. Translocates to the plasma membrane in response to steroid hormone receptor stimulation. Translocation to the plasma membrane is dependent on G-protein coupled receptor stimulation and subsequent activation of PRKCE and probably PRKCH. {ECO:0000250}.
SubunitInteracts with RHOA (constitutively activated, GTP- bound); the interaction inhibits DGKQ. Interacts with PRKCE. Interacts with PRKCH. Interacts with PLCB1. Interacts with NR5A1 (By similarity). {ECO:0000250}.