LMPD Database

LMP002729

UniProt Annotations

Entry Information
Gene Namehydroxysteroid 11-beta dehydrogenase 1
Protein EntryDHI1_MOUSE
UniProt IDP50172
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityAn 11-beta-hydroxysteroid + NADP(+) = an 11- oxosteroid + NADPH.
FunctionCatalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone.
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane; Single-pass type II membrane protein.
SubunitHomodimer. {ECO:0000269|PubMed:15865440}.
Tissue SpecificityWidely expressed. Highest expression in liver.