LMPD Database

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LMP002725

UniProt Annotations

Entry Information
Gene Namearylacetamide deacetylase (esterase)
Protein EntryAAAD_MOUSE
UniProt IDQ99PG0
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityTriacylglycerol + H(2)O = diacylglycerol + a carboxylate. {ECO:0000269|PubMed:19654421}.
FunctionDisplays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly (By similarity). Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity. {ECO:0000250, ECO:0000269|PubMed:19654421, ECO:0000269|PubMed:22207054}.
PtmN-glycosylated. {ECO:0000269|PubMed:19654421}.
SimilarityBelongs to the 'GDXG' lipolytic enzyme family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000269|PubMed:19654421}; Single-pass type II membrane protein {ECO:0000269|PubMed:19654421}. Microsome membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Tissue SpecificityHighest levels in liver with lower levels in jejunum and kidney. {ECO:0000269|PubMed:19654421, ECO:0000269|PubMed:22207054}.