LMPD Database

LMP002668

Gene Information

Entrez Gene ID	10891
Gene Name	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
Gene Symbol	PPARGC1A
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005829	IEA:Ensembl	C	cytosol
GO:0005665	TAS:UniProtKB	C	DNA-directed RNA polymerase II, core complex
GO:0005654	TAS:Reactome	C	nucleoplasm
GO:0005634	IDA:UniProtKB	C	nucleus
GO:0050681	NAS:UniProtKB	F	androgen receptor binding
GO:0031490	ISS:UniProtKB	F	chromatin DNA binding
GO:0003677	ISS:UniProtKB	F	DNA binding
GO:0016922	IPI:UniProtKB	F	ligand-dependent nuclear receptor binding
GO:0030374	IDA:BHF-UCL	F	ligand-dependent nuclear receptor transcription coactivator activity
GO:0000166	IEA:InterPro	F	nucleotide binding
GO:0003723	TAS:UniProtKB	F	RNA binding
GO:0001104	TAS:UniProtKB	F	RNA polymerase II transcription cofactor activity
GO:0043565	IDA:UniProtKB	F	sequence-specific DNA binding
GO:0003713	IDA:UniProtKB	F	transcription coactivator activity
GO:0008134	TAS:UniProtKB	F	transcription factor binding
GO:0031625	IPI:UniProtKB	F	ubiquitin protein ligase binding
GO:0008209	IEA:Ensembl	P	androgen metabolic process
GO:0030521	NAS:UniProtKB	P	androgen receptor signaling pathway
GO:0050873	TAS:UniProtKB	P	brown fat cell differentiation
GO:0001678	NAS:UniProtKB	P	cellular glucose homeostasis
GO:0045333	TAS:UniProtKB	P	cellular respiration
GO:0071398	IEA:Ensembl	P	cellular response to fatty acid
GO:0071456	IEA:Ensembl	P	cellular response to hypoxia
GO:0071250	IEA:Ensembl	P	cellular response to nitrite
GO:0034599	ISS:UniProtKB	P	cellular response to oxidative stress
GO:0097067	IEA:Ensembl	P	cellular response to thyroid hormone stimulus
GO:0071356	IEA:Ensembl	P	cellular response to tumor necrosis factor
GO:0032922	ISS:UniProtKB	P	circadian regulation of gene expression
GO:0007586	TAS:UniProtKB	P	digestion
GO:0019395	NAS:UniProtKB	P	fatty acid oxidation
GO:0051552	IEA:Ensembl	P	flavone metabolic process
GO:0006012	IEA:Ensembl	P	galactose metabolic process
GO:0006094	NAS:UniProtKB	P	gluconeogenesis
GO:0007005	NAS:UniProtKB	P	mitochondrion organization
GO:0006397	TAS:UniProtKB	P	mRNA processing
GO:0045820	IEA:Ensembl	P	negative regulation of glycolytic process
GO:0043524	ISS:UniProtKB	P	negative regulation of neuron apoptotic process
GO:1901215	IGI:UniProtKB	P	negative regulation of neuron death
GO:2000272	IEA:Ensembl	P	negative regulation of receptor activity
GO:2001171	ISS:UniProtKB	P	positive regulation of ATP biosynthetic process
GO:1901857	IEA:Ensembl	P	positive regulation of cellular respiration
GO:2000507	ISS:UniProtKB	P	positive regulation of energy homeostasis
GO:0046321	TAS:UniProtKB	P	positive regulation of fatty acid oxidation
GO:0045722	TAS:UniProtKB	P	positive regulation of gluconeogenesis
GO:0035066	TAS:UniProtKB	P	positive regulation of histone acetylation
GO:1901860	IEA:Ensembl	P	positive regulation of mitochondrial DNA metabolic process
GO:0010822	ISS:UniProtKB	P	positive regulation of mitochondrion organization
GO:1901863	IEA:Ensembl	P	positive regulation of muscle tissue development
GO:0051091	IDA:BHF-UCL	P	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0048661	IEA:Ensembl	P	positive regulation of smooth muscle cell proliferation
GO:0045893	NAS:UniProtKB	P	positive regulation of transcription, DNA-templated
GO:0045944	IDA:ParkinsonsUK-UCL	P	positive regulation of transcription from RNA polymerase II promoter
GO:0006461	TAS:UniProtKB	P	protein complex assembly
GO:0050821	TAS:UniProtKB	P	protein stabilization
GO:0042752	ISS:UniProtKB	P	regulation of circadian rhythm
GO:2000310	IEA:Ensembl	P	regulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:0006355	IDA:UniProtKB	P	regulation of transcription, DNA-templated
GO:0022904	ISS:UniProtKB	P	respiratory electron transport chain
GO:0009409	IEA:Ensembl	P	response to cold
GO:0071871	IEA:Ensembl	P	response to epinephrine
GO:0043201	IEA:Ensembl	P	response to leucine
GO:0014850	ISS:BHF-UCL	P	response to muscle activity
GO:0071873	IEA:Ensembl	P	response to norepinephrine
GO:0042594	NAS:UniProtKB	P	response to starvation
GO:0036273	IEA:Ensembl	P	response to statin
GO:0008380	TAS:UniProtKB	P	RNA splicing
GO:0001659	TAS:UniProtKB	P	temperature homeostasis
GO:0006367	TAS:UniProtKB	P	transcription initiation from RNA polymerase II promoter

KEGG Pathway Links

KEGG Pathway ID	Description
hsa04152	AMPK signaling pathway