LMPD Database

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LMP002662

UniProt Annotations

Entry Information
Gene Nameinositol hexaphosphate kinase 2
Protein EntryIP6K2_MOUSE
UniProt IDQ80V72
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6- pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.
Catalytic ActivityATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.
FunctionConverts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Was first identified because of its ability to stimulate Na(+)-dependent phosphate cotransport (By similarity). {ECO:0000250}.
SimilarityBelongs to the inositol phosphokinase (IPK) family. {ECO:0000305}.
Subcellular LocationNucleus {ECO:0000250}.
Tissue SpecificityHighly expressed in brain and lung, and at slightly lower levels in liver, kidney and testis. {ECO:0000269|PubMed:10574768}.