LMPD Database

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LMP002655

UniProt Annotations

Entry Information
Gene NameCDC-like kinase 1
Protein EntryCLK1_MOUSE
UniProt IDP22518
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=Long; IsoId=P22518-1; Sequence=Displayed; Name=Short; Synonyms=Clk1T; IsoId=P22518-2; Sequence=VSP_004854, VSP_004855; Note=Lacks the kinase domain.;
Catalytic ActivityATP + a protein = ADP + a phosphoprotein.
Enzyme RegulationRegulates splicing of its own pre-mRNA according to its kinase activity; increased expression of the catalytically active form influences splicing to generate the catalytically inactive splicing variant lacking the kinase domain. Leucettine L41 inhibits its kinase activity and affects the regulation of alternative splicing mediated by phosphorylation of SR proteins. {ECO:0000269|PubMed:21615147, ECO:0000269|PubMed:9315658}.
FunctionDual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA. {ECO:0000269|PubMed:9307018, ECO:0000269|PubMed:9315658}.
InteractionQ5ZRQ0:lubX (xeno); NbExp=3; IntAct=EBI-6479117, EBI-6402540;
PtmAutophosphorylates on all three types of residues. {ECO:0000269|PubMed:17242355, ECO:0000269|PubMed:9307018}.
SimilarityBelongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily. {ECO:0000305}.
SimilarityContains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
Subcellular LocationNucleus {ECO:0000269|PubMed:9307018}.
SubunitInteracts with PPIG and UBL5. {ECO:0000250}.