LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP002643

UniProt Annotations

Entry Information
Gene Namepiccolo presynaptic cytomatrix protein
Protein EntryQ9Y6V0_HUMAN
UniProt IDQ9Y6V0
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=6; Comment=Additional isoforms seem to exist.; Name=1; IsoId=Q9Y6V0-1; Sequence=Displayed; Name=2; IsoId=Q9Y6V0-2; Sequence=VSP_003923, VSP_003924, VSP_003925, VSP_003926, VSP_003927; Name=3; IsoId=Q9Y6V0-3; Sequence=VSP_012348, VSP_012349, VSP_003924, VSP_003926, VSP_003927; Note=No experimental confirmation available.; Name=4; IsoId=Q9Y6V0-4; Sequence=VSP_041005, VSP_041006; Note=No experimental confirmation available.; Name=5; IsoId=Q9Y6V0-5; Sequence=VSP_041004, VSP_041007, VSP_041008, VSP_003923, VSP_003924, VSP_003925, VSP_041009; Note=No experimental confirmation available.; Name=6; IsoId=Q9Y6V0-6; Sequence=VSP_041004, VSP_041007, VSP_041008, VSP_003923, VSP_003924, VSP_003925, VSP_003926, VSP_003927; Note=No experimental confirmation available.;
DomainC2 domain 1 is involved in binding calcium and phospholipids. Calcium binds with low affinity but with high specificity and induces a large conformational change.
FunctionMay act as a scaffolding protein involved in the organization of synaptic active zones and in synaptic vesicle trafficking.
Sequence CautionSequence=AAB97937.1; Type=Erroneous gene model prediction; Evidence= ; Sequence=AAD21789.2; Type=Erroneous gene model prediction; Evidence= ;
SimilarityContains 1 PDZ (DHR) domain.
SimilarityContains 2 C2 domains. {ECO
Subcellular LocationCell junction, synapse . Note=Concentrated at the presynaptic side of synaptic junctions.
SubunitInteracts with RABAC1/PRA1, RIMS2 and profilin.