LMPD Database

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LMP002637

UniProt Annotations

Entry Information
Gene NameATP-binding cassette, sub-family B (MDR/TAP), member 11
Protein EntryABCBB_HUMAN
UniProt IDO95342
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=30.4 uM for taurocholate ; Vmax=232 pmol/min/mg enzyme for taurocholate transport ;
DiseaseCholestasis, benign recurrent intrahepatic, 2 (BRIC2) [MIM
DiseaseCholestasis, progressive familial intrahepatic, 2 (PFIC2) [MIM
DomainMultifunctional polypeptide with two homologous halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain.
FunctionInvolved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.
SimilarityBelongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
SimilarityContains 2 ABC transmembrane type-1 domains.
SimilarityContains 2 ABC transporter domains.
Subcellular LocationMembrane; Multi-pass membrane protein.
SubunitInteracts with HAX1.
Tissue SpecificityExpressed predominantly, if not exclusively in the liver, where it was further localized to the canalicular microvilli and to subcanalicular vesicles of the hepatocytes by in situ.
Web ResourceName=ABCMdb; Note=Database for mutations in ABC proteins; URL="http://abcmutations.hegelab.org/proteinDetails?uniprot_id=O95342";