LMPD Database

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LMP002629

UniProt Annotations

Entry Information
Gene Namealdehyde dehydrogenase 2 family (mitochondrial)
Protein EntryALDH2_HUMAN
UniProt IDP05091
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P05091-1; Sequence=Displayed; Name=2; IsoId=P05091-2; Sequence=VSP_046715; Note=No experimental confirmation available.;
Catalytic ActivityAn aldehyde + NAD(+) + H(2)O = a carboxylate + NADH.
PathwayAlcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.
PolymorphismGenetic variation in ALDH2 is responsible for individual differences in responses to drinking alcohol [MIM
Sequence CautionSequence=AAA62825.1; Type=Frameshift; Positions=424, 444, 448, 461; Evidence= ; Sequence=CAA68290.1; Type=Frameshift; Positions=Several; Evidence= ; Sequence=CAA68290.1; Type=Miscellaneous discrepancy; Evidence= ;
SimilarityBelongs to the aldehyde dehydrogenase family.
Subcellular LocationMitochondrion matrix.
SubunitHomotetramer.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/ALDH2ID250.html";