LMPD Database

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LMP002606

UniProt Annotations

Entry Information
Gene Namedual adaptor of phosphotyrosine and 3-phosphoinositides
Protein EntryDAPP1_HUMAN
UniProt IDQ9UN19
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; Synonyms=hBam1; IsoId=Q9UN19-1; Sequence=Displayed; Name=2; Synonyms=hBam2; IsoId=Q9UN19-2; Sequence=VSP_010699;
FunctionMay act as a B-cell-associated adapter that regulates B- cell antigen receptor (BCR)-signaling downstream of PI3K.
InductionUpon B-cell activation.
PtmPhosphorylated on tyrosine residues.
SimilarityContains 1 PH domain. {ECO
SimilarityContains 1 SH2 domain. {ECO
Subcellular LocationCytoplasm . Membrane ; Peripheral membrane protein . Note=Membrane-associated after cell stimulation leading to its translocation.
SubunitInteracts with PtdIns(3,4,5)P3 and PLCG2. In vitro, interacts with PtdIns(3,4)P2. {ECO
Tissue SpecificityHighly expressed in placenta and lung, followed by brain, heart, kidney, liver, pancreas and skeletal muscle. Expressed by B-lymphocytes, but not T-lymphocytes or nonhematopoietic cells.