LMPD Database

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LMP002591

UniProt Annotations

Entry Information
Gene Nameretinol dehydrogenase 11
Protein EntryRDH11_MOUSE
UniProt IDQ9QYF1
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=1; Comment=A number of isoforms are produced.; Name=1; IsoId=Q9QYF1-1; Sequence=Displayed;
Catalytic ActivityAll-trans-retinol + NADP(+) = all-trans- retinal + NADPH.
FunctionExhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent all-trans-retinal reductase. Also involved in the metabolism of short-chain aldehydes.
PtmNot glycosylated. {ECO:0000250}.
Sequence CautionSequence=BAA88521.1; Type=Frameshift; Positions=311; Evidence={ECO:0000305};
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Tissue SpecificityExpressed at higher level in liver and testis. Expressed at lower levels in smooth muscle, thymus, submaxillary gland and epididymis. In testis, expression is restricted to pachytene spermatocytes. Also expressed in four layers of the retina, including the outer segment of rods and cones.