LMPD Database

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LMP002586

UniProt Annotations

Entry Information
Gene Name3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2
Protein EntryHMCS2_MOUSE
UniProt IDP54869
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityAcetyl-CoA + H(2)O + acetoacetyl-CoA = (S)-3- hydroxy-3-methylglutaryl-CoA + CoA. {ECO:0000255|PROSITE- ProRule:PRU10116}.
FunctionThis enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
PathwayMetabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 2/3.
PtmAcetylation of Lys-427 is observed in liver mitochondria from fasted mice but not from fed mice. {ECO:0000269|PubMed:23576753}.
SimilarityBelongs to the HMG-CoA synthase family. {ECO:0000305}.
Subcellular LocationMitochondrion.
SubunitHomodimer. {ECO:0000250}.
Tissue SpecificityLiver and kidney.