LMPD Database

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LMP002580

UniProt Annotations

Entry Information
Gene Namefarnesyltransferase, CAAX box, beta
Protein EntryFNTB_HUMAN
UniProt IDP49356
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P49356-1; Sequence=Displayed; Name=2; IsoId=P49356-2; Sequence=VSP_054657; Note=No experimental confirmation available.;
Catalytic ActivityFarnesyl diphosphate + protein-cysteine = S- farnesyl protein + diphosphate. {ECO
CofactorName=Zn(2+); Xref=ChEBI
FunctionEssential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C- terminus of several proteins having the C-terminal sequence Cys- aliphatic-aliphatic-X. {ECO
InteractionP49354:FNTA; NbExp=7; IntAct=EBI-602349, EBI-602336;
SimilarityBelongs to the protein prenyltransferase subunit beta family.
SimilarityContains 5 PFTB repeats.
SubunitHeterodimer of FNTA and FNTB. {ECO