LMPD Database

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LMP002565

UniProt Annotations

Entry Information
Gene Namephosphatidylserine synthase 1
Protein EntryPTSS1_MOUSE
UniProt IDQ99LH2
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityL-1-phosphatidylethanolamine + L-serine = L-1- phosphatidylserine + ethanolamine.
Disruption PhenotypeNull mice are viable, fertile and have a normal life span. Toal serine exchange is reduced up to 85%, but apart from in liver, the phosphatatidylserine content was unaltered. Elimination of either Pss1 or Pss2, but not both, is compatible with mouse viability. Mice can tolerate as little as 10% serine-exchange activity and are viable with small amounts of phosphatidylserine and phosphatidylethanolamine content. to phosphatidylethanolamine. {ECO:0000269|PubMed:18343815}.
Enzyme RegulationPotently inhibited by choline in the mitochondria-associated membrane (MAM). Very little inhibition by choline in the endoplasmic reticulum (ER) per se. {ECO:0000269|PubMed:10938271}.
FunctionCatalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. In membranes, PTDSS1 catalyzes mainly the conversion of phosphatidylcholine. Also converts, in vitro and to a lesser extent, phosphatidylethanolamine. {ECO:0000269|PubMed:10432300, ECO:0000269|PubMed:9516423}.
PathwayPhospholipid metabolism; phosphatidylserine biosynthesis.
SimilarityBelongs to the phosphatidyl serine synthase family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000269|PubMed:10938271}; Multi-pass membrane protein {ECO:0000269|PubMed:10938271}. Note=Highly enriched in the mitochondria-associated membrane (MAM).
Tissue SpecificityExpressed in kidney, testis, lung, skeletal muscle, liver brain, heart and spleen with highest expression in testis, liver, heart and brain. {ECO:0000269|PubMed:10432300}.