LMPD Database

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LMP002546

UniProt Annotations

Entry Information
Gene Namefarnesyl diphosphate farnesyl transferase 1
Protein EntryFDFT_MOUSE
UniProt IDP53798
SpeciesMouse
Comments
Comment typeDescription
Catalytic Activity2 farnesyl diphosphate + NAD(P)H = squalene + 2 diphosphate + NAD(P)(+).
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420;
FunctionCritical branch point enzyme of isoprenoid biosynthesis that is thought to regulate the flux of isoprene intermediates through the sterol pathway.
PathwayTerpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3.
SimilarityBelongs to the phytoene/squalene synthase family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane; Multi-pass membrane protein.