LMPD Database

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LMP002540

UniProt Annotations

Entry Information
Gene Name1-acylglycerol-3-phosphate O-acyltransferase 3
Protein EntryPLCC_HUMAN
UniProt IDQ9NRZ7
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Gamma-1; IsoId=Q9NRZ7-1; Sequence=Displayed; Name=2; Synonyms=Gamma-2; IsoId=Q9NRZ7-2; Sequence=VSP_005072; Name=3; IsoId=Q9NRZ7-3; Sequence=VSP_013144; Note=No experimental confirmation available.;
Biophysicochemical PropertiesKinetic parameters: KM=4.78 uM for LPA sn-1 C18:1 ; KM=21.53 uM for C18:1-CoA ; Vmax=6.35 nmol/min/mg enzyme toward LPA sn-1 C18:1 ; Vmax=0.74 nmol/min/mg enzyme toward C18:1-CoA ;
Catalytic ActivityAcyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.
DomainThe HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
FunctionConverts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C16:0-C20:4 at the sn-1 position using C18:1, C20:4 or C18:2-CoA as the acyl donor. Also acts on lysophosphatidylcholine, lysophosphatidylinositol and lysophosphatidylserine using C18:1 or C20:4-CoA.
PathwayPhospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.
SimilarityBelongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
Subcellular LocationEndoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus envelope.
Tissue SpecificityWidely expressed with highest levels in testis, pancreas and kidney, followed by spleen, lung, adipose tissue and liver.