LMPD Database

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LMP002539

UniProt Annotations

Entry Information
Gene Namepancreatic lipase
Protein EntryLIPP_MOUSE
UniProt IDQ6P8U6
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityTriacylglycerol + H(2)O = diacylglycerol + a carboxylate. {ECO:0000269|PubMed:10769148}.
FunctionPlays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones (By similarity). {ECO:0000250}.
InductionBy colipase/CLPS in the presence of bile salts.
SimilarityBelongs to the AB hydrolase superfamily. Lipase family. {ECO:0000305}.
SimilarityContains 1 PLAT domain. {ECO:0000255|PROSITE- ProRule:PRU00152}.
Subcellular LocationSecreted {ECO:0000250}.
Tissue SpecificityPancreas. {ECO:0000269|PubMed:10769148}.