LMPD Database

LMP002524

Gene Information

Entrez Gene ID	21898
Gene Name	toll-like receptor 4
Gene Symbol	Tlr4
Species	Mus musculus

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0009897	IEA:Ensembl	C	external side of plasma membrane
GO:0005887	IEA:Ensembl	C	integral component of plasma membrane
GO:0046696	IEA:Ensembl	C	lipopolysaccharide receptor complex
GO:0048471	IEA:Ensembl	C	perinuclear region of cytoplasm
GO:0004888	IEA:InterPro	F	transmembrane signaling receptor activity
GO:0002218	IMP:MGI	P	activation of innate immune response
GO:0002322	IMP:MGI	P	B cell proliferation involved in immune response
GO:0071222	IDA:MGI	P	cellular response to lipopolysaccharide
GO:0071223	IMP:MGI	P	cellular response to lipoteichoic acid
GO:0071260	IEA:Ensembl	P	cellular response to mechanical stimulus
GO:0050829	IMP:MGI	P	defense response to Gram-negative bacterium
GO:0032497	IEA:Ensembl	P	detection of lipopolysaccharide
GO:0007252	IMP:MGI	P	I-kappaB phosphorylation
GO:0045087	IEA:UniProtKB-KW	P	innate immune response
GO:0032609	IGI:MGI	P	interferon-gamma production
GO:0031663	IDA:MGI	P	lipopolysaccharide-mediated signaling pathway
GO:0042116	IEA:Ensembl	P	macrophage activation
GO:0002755	IEA:InterPro	P	MyD88-dependent toll-like receptor signaling pathway
GO:0002537	IMP:MGI	P	nitric oxide production involved in inflammatory response
GO:0030890	IMP:MGI	P	positive regulation of B cell proliferation
GO:0032722	IEA:Ensembl	P	positive regulation of chemokine production
GO:0070374	IDA:MGI	P	positive regulation of ERK1 and ERK2 cascade
GO:0043123	IDA:MGI	P	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045359	IMP:MGI	P	positive regulation of interferon-beta biosynthetic process
GO:0032733	IDA:MGI	P	positive regulation of interleukin-10 production
GO:0045084	IEA:Ensembl	P	positive regulation of interleukin-12 biosynthetic process
GO:0032755	IDA:MGI	P	positive regulation of interleukin-6 production
GO:0045416	IEA:Ensembl	P	positive regulation of interleukin-8 biosynthetic process
GO:0032757	IEA:Ensembl	P	positive regulation of interleukin-8 production
GO:0046330	IDA:MGI	P	positive regulation of JNK cascade
GO:0050671	IMP:MGI	P	positive regulation of lymphocyte proliferation
GO:0060907	IMP:MGI	P	positive regulation of macrophage cytokine production
GO:0045348	IMP:MGI	P	positive regulation of MHC class II biosynthetic process
GO:0042346	IEA:Ensembl	P	positive regulation of NF-kappaB import into nucleus
GO:0051092	IEA:Ensembl	P	positive regulation of NF-kappaB transcription factor activity
GO:0045429	IMP:MGI	P	positive regulation of nitric oxide biosynthetic process
GO:0070430	IDA:MGI	P	positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070434	IDA:MGI	P	positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0032874	IDA:MGI	P	positive regulation of stress-activated MAPK cascade
GO:0042535	IEA:Ensembl	P	positive regulation of tumor necrosis factor biosynthetic process
GO:0032760	IDA:MGI	P	positive regulation of tumor necrosis factor production
GO:0050707	IEA:InterPro	P	regulation of cytokine secretion
GO:0009617	IMP:MGI	P	response to bacterium
GO:0032496	IMP:MGI	P	response to lipopolysaccharide
GO:0034142	IEA:InterPro	P	toll-like receptor 4 signaling pathway